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Author: VWheelock

29. Statins and Diabetes

A major study has reported that women who use statins have a much higher risk of developing diabetes mellitus(DM) when compared women who do not. This is one the results obtained in the Women’s Health Initiative(WHI) which is being conducted in the USA(1). The WHI recruited 161,808 postmenopausal women aged 50 to 79 years at 40clinical centres across the USA between 1993 and 1998. This study is based on an analysis of data available up to 2005 from 153,840 participants. Of these 10,834 were statin users. The average age of all those involved was just over 63 years. Those who used statins had an incidence of DM which was 71% higher than those who did not. The increased risk of DM was observed for all types of statin. There was no difference between high- and low-potency statins. One particularly interesting feature of the results was the relatively high risk of developing DM in those who had a BMI of 25 or less. This BMI is considered to be the ideal but nevertheless statin users had more than double the risk of developing DM as compared with the non-users. TABLE 1 VARIATION IN RELATIVE RISK OF DEVELOPING DIABETES WITH BODY MASS INDEX(BMI) BMI STATIN USER RELATIVE RISK <25.0 YES 2.50 NO 1.00(Reference) 25.0-29.9 YES 1.91 NO 1.00(Reference) >30.0 YES 1.23 NO 1.00(Reference)   It is absolutely crucial to recognise that...

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28.Low Cholesterol and Violent Behaviour

There is now ample evidence to show that low cholesterol (TC) per se is linked to a range of adverse side-effects including an increase in the incidence of violent deaths and suicide. A meta-analysis found that observational studies (including cohort, case–control, and cross-sectional studies) consistently showed increased violent death and violent behaviours in persons with low TC levels. Some meta-analyses of randomized trials found excess violent deaths in men without heart disease who were receiving cholesterol-lowering therapy. Experimental studies showed increased violent behaviours in monkeys assigned to low-cholesterol diets. Human and animal research indicates that low or lowered TC levels may reduce central serotonin activity, which in turn is causally linked to violent behaviour. Many trials support a significant relation between low or lowered TC levels and violence (1). In 1990, Muldoon conducted a review of 6 different trials to study the effect of cholesterol-lowering (2). These involved 24,847 men whose mean age was 47.5 years. The follow-up period consisted of 119,000 person-years and 1,147 deaths. It was confirmed that deaths from heart disease did decrease as the TC was lowered but deaths from other causes increased so that the all-cause mortality was not altered. Although there were 28 fewer deaths from CHD there were actually 29 more deaths from suicides and murder. The realities of the violent behaviour that can arise as a result of the use of...

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27. Side-Effects of Statins

  The justification for the prescription of statins is that they lower the level of cholesterol in the blood(TC). As a consequence it is argued there will be a reduction in the risk of developing heart disease. However as I have demonstrated in previous blogs (BLOGS 8 and 14)this argument does not stand up to rigorous examination. When investigations have been done which specifically consider the effect of statin therapy on the incidence of heart disease the results are by no means clear-cut. Essentially this is what has been discovered: In all women there is absolutely no reliable evidence to show that there is any improvement in life expectancy The same result has been obtained for men who have not suffered from heart disease For men who have had heart disease there is a marginal improvement but this is very small. It is necessary to treat 50 men for 5 years in order that one will benefit! On the other hand there are numerous reports of damaging side-effects which are related to the use of the statin medication. Here are 3 case studies from patients who visited hospitals in North Wales (1). A 63-year-old lady had pains in her right thigh and knee which she believed had been caused by a 3-mile walk while she was on holiday. A month after her initial visit she returned to the hospital...

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26.Statin Nation: The Great Cholesterol Cover-up

The above is the title of a film made by Justin Smith which describes the way in which science is being manipulated and corrupted in order to underpin the sales of statins which generate billions of dollars for the pharmaceutical industry every year. For a short period this film can be viewed free of charge using the link below: Although it lasts for just over an hour I strongly recommend that as many people as possible take the time to view. Here are just a few of the points which are dealt with in the film: The original work by Ancel Keyes which is the foundation of the Diet/Heart Theory is fundamentally flawed. Keys used data from 6 countries to show that there is a good relationship between the amount of fat in the diet, the cholesterol in the blood and the incidence of heart disease. If he had included data from 22 countries which were available then he would have found that such relationships simply did not exist. Information from the British Heart Foundation shows that in Great Britain for men aged 65-74 there has been a fall in the proportion with high cholesterol from 87% in 1994to 54% in 2006 yet the prevalence of heart disease has remained constant at 21%. In Great Britain, women in the lower socio-economic groups are 5 times more likely to...

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25. More about the Polyunsaturates

In BLOG 15, I explained that there are serious doubts about the rationale which underpins the recommendation to increase the intake of polyunsaturates (PUFAs) which are the omega-6 fatty acids(omega 6s). Nevertheless foods which are high in PUFAs continue to be promoted as healthy. As recently as 2009 the American Heart Association (AHA) reviewed its position. It was concluded that the combined results of a range of studies provided: “ evidence that replacing saturated fat or refined carbohydrates….with omega-6 PUFAs reduces        CHD risk” It went on to recommend that consumption of at least 5% to 10% of energy from omega 6s would reduce the risk of heart disease relative to lower intakes. Furthermore higher levels appear to be safe and would probably be beneficial(1). However the quality of much of the research used to justify this recommendation has been seriously questioned. In a thorough examination of the relevant critical investigations, Chris Ramsden and colleagues discovered that in a number of these trials mixtures of omega-3s and omega-6s were actually used but it had been assumed that only omega 6s were present. When the investigations were separated into those which contained mixtures and those which consisted of omega-6s only a very different picture emerges. Those with mixed omega-3/omega-6s did actually result in a significant reduction in the risks of non-fatal heart attacks of 27%. For non-fatal heart attacks plus CHD...

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  • There is simply no reasonable scientific justification for official advice to consume very low intakes of salt.
    about 25 mins ago
  • Tim Noakes responds to the charges at the hearing in South Africa. Devastating critique of US Dietary Guidelines.
    about 45 mins ago
  • PHE advises unbelievable intakes of carbs. Even higher than the dubious SACN recommendations.
    about 1 hour ago
  • Why are patients not always presented with the harsh reality of the dangers of medical practice before treatment?
    about 1 hour ago
  • The PM suffers from Type 1 Diabetes. She should shake up current NHS disastrous policy on diabetes.
    about 2 hours ago